Frequently Asked Questions

Kaléo Medical Affairs is the medical affairs division of Kaleo, Inc. This site provides scientific and medical information related to anaphylaxis with specific considerations for infants and toddlers. It is intended primarily for U.S. healthcare professionals who manage patients at risk for anaphylaxis. Selected resources are also available for healthcare providers to share with patients and caregivers.

Healthcare professionals can access peer-reviewed publications, congress-presented research, evidence-based clinical and practice guidelines, anaphylaxis management resources, and downloadable educational materials. These resources are designed to support clinical decision-making and conversations with caregivers, with particular attention to the challenges associated with recognizing and managing anaphylaxis in infants and toddlers.

The site provides access to standardized allergy and anaphylaxis emergency-plan templates for use in homes, schools, childcare programs, and other community settings developed by leading professional medical societies, patient advocacy organizations, and public health agencies. These plans can be customized by you, the healthcare provider, based on individualized needs of your patients to ensure action plans are in place for appropriate emergency response.

The Publications section includes Kaléo-supported peer-reviewed manuscripts and congress presentations addressing anaphylaxis epidemiology, recognition, treatment, caregiver experiences, epinephrine auto-injector design, and real-world outcomes. Each listing links to the source journal, PubMed record, or another available source. Selected congress posters may also be available for direct download. Access to articles behind a paywall may be available through the publisher or your institution’s library.

Current clinical guidance includes the 2023 Joint Task Force Practice Parameter Update on anaphylaxis which provides evidence-based recommendations on diagnosis, risk assessment, epinephrine use and management. These guidelines include updated diagnostic criteria and age-specific considerations of infants and toddlers for epinephrine use. A link to the full text of this guideline is available in the Practice Guidelines section of this page.

Anaphylaxis symptoms in pre-verbal infants and toddlers may be more difficult to recognize than in older children or adults. Published research indicates that symptom patterns including skin changes, gastrointestinal symptoms, respiratory signs, and behavioral changes may signal anaphylaxis amongst this age group. Current practice guidelines provide age-specific diagnostic criteria to support clinical recognition. Please refer to the publications and resources on this site for further detail regarding age-specific diagnostic criteria to support clinical recognition.

Epinephrine dose and needle length should be considered when selecting an auto-injector to treat patients in lower weight ranges according to published research and practice guidelines. Resources and clinical references addressing this topic are available in the Publications section of this site.

If your question is not addressed by the publications or resources available on this site, you may submit an inquiry through the Contact Us form. Select the appropriate inquiry topic and provide your profession, specialty, subject, and sufficient detail about your request to help the Kaléo Medical Affairs team respond appropriately within 2 business days.

Yes. The Resources for HCPs section includes downloadable materials designed to support discussions with caregivers about recognizing anaphylaxis, responding to an allergic emergency and using epinephrine.